Pharmaceutical Raw Material Lincomycin Hydrochloride HCl CAS: 859-18-7

Basic info.

Lincomycin Hcl 

Synonyms: Lincomycin Hydrochloride

CAS: 859-18-7

EINECS: 212-726-7   

Assay: 82.5~95.5%

Packing: 20Bou/cardboard drum

MF: C18H35ClN2O6S

MW: 443

Description:

Lincomycin kills bacteria by interfering with the ability of bacteria to produce important proteins necessary for them to survive. Lincomycin is effective against many types of bacteria including Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Propionibacterium acnes, and others. Use of lincomycin is reserved for penicillin-allergic patients or when penicillin-based treatment is not appropriate. This antibiotic should only be used to treat serious infections because of rare but sometimes fatal intestinal problems have occurred. The specific infections for which LINCOCIN is used include: Ear, throat and lung infections; Skin infections; Bone and joint infections; And infections of the blood. LINCOCIN will not work against viral infections such as colds or flu.

Applications: 

An antibiotic produced by Streptomyces lincolnensis. Lincomycin is a lincosamide antibiotic .An antibiotic produced by Streptomyces lincolnensis. Lincomycin is a lincosamide antibiotic that forms cross-links within the peptidyl transferase loop region of the 23S rRNA. Inhibits bacterial protein synthesis. Antibacterial.

Lincomycin (hereinafter referred to as LCM) biosynthesis, in addition to produce LCM, but under certain conditions, also produced the LCM B, C, D, K, S and other analogues, thus refining process more difficult and costly.

LD50 acute toxicity test showed that mice injected 1000mg/kg, rat oral greater than 4000mg/kg, toxicity is low.

Indications: Effect as erythromycin, do not have to do skin test, the product of Gram-positive bacteria and gram-negative bacteria is stronger for osteomyelitis, sepsis, respiratory and soft tissue infections. This product is very strong penetration of bone, is the medicine of choice for osteomyelitis.