4-Hydroxybutyric Acid Gamma-Lactone, G-Butyrolactone/ Blo/ 2-Oxolanone/ Y-Butyrolactone Solvent

Basic info.

Product Name: Butyrolactone ,Gamma Butyrolactone

Synonyms:1-Oxacyclopentan-2-one;2(3H)-dihydrofuranone;2(3H)-Furanone, dihydro-;2(3H)-furanone,dihydro-;2,3,4,5-tetrahydro-2-furanone;2-Oxolanone;2-Oxotetrahydrofuran;3-Hydroxybutyric acid lactone

MF: C4H6O2

MW: 86.09

EINECS: 202-509-5

Product Categories: Pharmaceutical Intermediates;Heterocycles;Miscellaneous Reagents

Description:

Butyrolactone (γ-butyrolactone or ) is a hygroscopic colorless liquid with a weak characteristic odor which is soluble in water.  is a common solvent and reagent in chemistry as well as being used as a flavouring, as a cleaning solvent, as a superglue remover, and as a solvent in some wet aluminium electrolytic capacitors. In humans it acts as a prodrug for, and it is used as a recreational intoxicant with effects similar to alcohol.

Butyrolactone has been found in extracts from samples of unadulterated wines.[3] This finding indicates that Butyrolactone is a naturally occurring component in some wines and may be present in similar products. The concentration detected was approximately 5 μg/mL and was easily observed using a simple extraction technique followed by GC/MS analysis. Butyrolactone can be found in cheese flavourings but typically results in a content of 0.0002% Butyrolactone in the final foodstuff.

Under acidic conditions it forms an equilibrium mixture of both compounds. These compounds then may go on to form a polymer. When treated with a non-nucleophilic base, like lithium diisopropylamide, Butyrolactone can become an alpha-carbon nucleophile. The related compound caprolactone can be used to make a polyester in this manner.

Butyrolactone is not active in its own right; its mechanism of action stems from its identity as a prodrug of .

The hypnotic effect of  is enhanced by combination with alcohol. A 2003 rat study showed that Butyrolactone in combination with ethanol showed a potentiated hypnotic effect, as the sleep-timing measure was longer than both of the individual components combined

Butyrolactone is rapidly converted into  by paraoxonase (lactonase) enzymes, found in the blood.[7][8] Animals which lack these enzymes exhibit no effect from Butyrolactone.[7] Butyrolactone is more lipophilic (fat soluble) than, and so is absorbed faster and has higher bioavailability. Because of these pharmacokinetic differences, Butyrolactone tends to be more potent and faster-acting than, but has a shorter duration; whereas the related compound 1,4-butanediol (1,4-B) tends to be slightly less potent, slower to take effect but longer-acting than.

Applications:

1) Used to produce a-pyrrolidone, 1-Methyl-2-pyrrolidinone, polyvinyl pyrrolidone, and α -Acetyl-γ -

    butyrolactone;

2) used as anaesthetic and tranquilizer, used to produce ciprofloxacin and interferon, as the intermediate of vitamin and rolicyprine;

3) As antioxidant, plasticizer, extractant, adsorbent, dispersant, fixative and curing agent;

4) Used in battery, capacitor and development of color film.

R-butyrolactone is an important organic chemical raw material, which is widely used in the pharmaceutical, pesticide, petrochemical and other industries. 

1 )  It can be used to synthesize pyrrolidone products; 

2 )  It can be used as a pharmaceutical intermediate, such as Cyclopropylamine and vitamin; 

3 )  It can be used as a pesticide intermediate, such as herbicide and plant growth regulator; 

4 )  It can be used for alkenes, alkynes extraction agent, absorbent and dispersing agent; 

5 )  It can be used to synthesize resin as an antioxidant, plasticizer, dispersing agent, fixing agent and solvent; 

6 )  It can be used to synthesize fiber spinning solvent, coagulant, dyeing assistant and antistatic agent; 

7 )  It can be used as a raw material of color film former, electrolyte, capacitor and ink lubricant.