Basic info:

Copper peptide
Glycyl-L-Histidyl-L-Lysine
Synonyms:Glycyl-histidyl-lysine; Copper glycyl-histidyl-lysine; Copper(II)ghk; Gly-his-lys; Glycylhistidyllysine; Iamin; NSC 379527; N(2)-(N-Glycyl-L-histidyl)-L-lysine; Copper peptide; GHK-Cu
CAS RN.: 49557-75-7
Molecular Weight: 340.3782
Molecular Formula: C14H24N6O4
Density: 1.324g/cm3
Boiling Point(ºC): 831°C at 760 mmHg
Flash Point(ºC):456.4°C
refractive_index: 1.582

GHK-Cu Description:

Copper peptide products are used for wound healing (Iamin, BioHeal),skin renewal (Blue Copper, Neova, Neutrogena copper, P&R), and hair growth (Tricomin, Graftcyte).

Copper is an important trace element that has been found to be important in wound healing and enzymatic processes.Lysyloxidase is an important enzyme in collagen and elastin production and it is dependent upon the action of copper.

Tyrosinase and cytochrome c oxidase require copper as well.The detrimental effects of free radicals on the skin have been elucidated in basic science research into skin photoaging. Superoxide dismutase acts as an important antioxidant and requires copper as a cofactor.

The peptide GHK spontaneously complexes with copper and facilitates the uptake of copper by cells. This peptide sequence is found in proteins of the extracellular matrix such as the αchain of collagen, and it is believed to be released during wounding and inflammation.

A feedback stimulation of collagen repair has also been proposed for this peptide, but the main benefit to photoaged skin is believed to be the enhanced delivery of copper.

GHK-Cu Application:

Copper-Peptides are used clinically for wound healing, increased skin healing after laser resurfacing and chemical peels, and for improving the success of hair transplantation.

They help stimulate the skin's remodeling and regenerative processes which repair the skin's protective outer barrier, increase new capillary formation (angiogenesis), increase the production of collagen and elastin which improve skin elasticity and firmness, and increase the water-holding proteoglycans and glycosaminoglycans (GAGs) which hold moisture in the skin and are the only "true" moisturizers of skin.

They also activate the skin's system (called metalloproteinases) which removes damaged proteins such as in scars and sun damage marks.

Copper-Peptides also improve the skin's anti-oxidant defenses by activating superoxide dismutase (SOD), a protein which de-toxifies free radicals and that is the body's primary anti-oxidant defense. Normally SOD lacks enough copper to be active and Copper-Peptides, by supplying nutritional copper to SOD, increase the activity of SOD.

When Copper-Peptides are applied to the skin, only very small amounts of the Copper-Peptides penetrate into the skin. Copper-Peptides have passed numerous safety tests. Scientific studies of Copper-Peptides have found that the amount of copper taken into the body from such Copper-Peptide creams is insignificant and does not raise total blood copper levels.

However, the microscopic amount of Copper-Peptides that do enter the skin's upper layer is sufficient to help stimulate skin regeneration.

Copper-Peptides, in every comparative clinical study, have been proven superior to Retin-A(R), Vitamin C creams, and Kinerase(R) in terms of wrinkle reduction, reducing skin blotchiness, improving skin firmness, and the development of new collagen.

Function:

- Accelerate wound repair
- Increase skin re-epithelialization
- Reverse aging effects on skin
- thickens skin, improves elasticity, and increases subcutaneous fat layer
- Improve hair transplant success ,prevent hair loss
- GHK analogs with fatty residue analogs increase hair follicle size, stimulate hair growth and reduce hair loss
- Heal injure intestinal linings . Activates skin's main antioxidant protein - superoxide dismutase