Anesthesia Prilocaine 721-50-6 Effective Pain Reliver Topical

prilocaine Profile

Product Name: Prilocaine

Synonyms: 2-(propylamino)-o-propionotoluidid;

CAS: 721-50-6

MF: C13H20N2O

MW: 220.31

EINECS: 211-957-0

Product Categories: Active Pharmaceutical Ingredients

Packing:Foil bag or as requirments

Pharmacological effects of prilocaine

Amide family of local anesthetics, the role of similar to lidocaine, but a longer time. No vasodilator effect, less toxic, accumulation is also small.

Pharmacokinetics of prilocaine

A considerable part of the lung metabolism or separation (sequester), in the body by the rapid degradation of the liver metabolism, toxicity than lidocaine.

Indications of prilocaine

For epidural anesthesia, block anesthesia and infiltration anesthesia.

Contraindications of prilocaine

Anemia, congenital or spontaneous degeneration of hemoglobin patients disabled, pregnant women with caution.

Precautions

1. Currently no longer commonly used clinically, mainly for local infiltration anesthesia and local intravenous anesthesia.

2. A maximum of 600mg.

Adverse effects of prilocaine

When the dose of more than 600mg, the metabolism of o-toluidine, hemoglobin reduction for the hemoglobin, and the blood methemoglobin more than 1.5g / dl, the clinical may be cyanosis, hemoglobinuria and other complications. In the event, to be 1mg / kg of methylene blue can be effective treatment of methemoglobinemia.

Dosage of prilocaine

Infiltration anesthesia with 1% solution; a variety of nerve block or epidural anesthesia with 2% or 3% solution.

Interaction of prilocaine with other drugs

In patients receiving other medications (such as sulfonamides) that can cause methemoglobinemia, prilocaine can aggravate methemoglobin formation. See lidocaine hydrochloride.