Product Details

Quick details:

 

Product name: Testosterone Undecanoate
Alias: Andriol
CAS No:5949-44-0
Einecs No: 227-712-6
MF: C30H48O3
MW: 456.7

Melting point 59-61°C
storage temp. Controlled Substance, -20?C Freezer

Product catagory: Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Steroids;

Steroid and Hormone;Finished Steroid and Hormone;API;testosterone

Usage: A metabolite of Testosterone. CONTROLLED SUBSTANC ;  A metabolite of Testosterone (T155000). It is a promising androgen for male hormonal contraception.

 

 

OBJECTIVE:

 

We determined the effect of 3 months of daily, 40 mg oral testosterone undecanoate on growth, body composition, hand grip and quadriceps muscle strength, and total free-living daily energy expenditure in boys with constitutionally delayed puberty.

 

MEASUREMENTS:

 

Body composition measurements were made by skinfold thickness, bioelectrical impedance and stable isotope dilution (H2(18)O) methods. Energy expenditure was assessed by the doubly-labelled water (2H2(18)O) technique.

 

RESULTS:

 

Height velocity increased from 5.4 (0.8) to 8.1 (0.6) cm/year (P < 0.05) in the 3 months after active therapy. Fat-free mass increased more with therapy (2.7 (0.3) kg) over the 6-month study period than with placebo (1.7 (0.4) kg, P < 0.5). Height velocity increases correlated with daily increases in fat-free mass (r = 0.68, P = 0.005) in the study group as a whole. Energy expenditure and muscle strength increased similarly in both groups. Predicted adult height decreased in the group which was treated with testosterone undecanoate.

 

CONCLUSIONS:

 

Testosterone undecanoate (40 mg daily for 3 months) significantly increased height velocity and fat-free mass velocities after 6 months but not muscle strength, endurance or total daily energy expenditure.

 

 

Testosterone undecanoate Quality Analysis Certificate

 

Test Items	Specification	Test Results
Appearance	White or almost white crystalline powder	Conform
Loss on drying	≦0.5%	0.24%
Optical rotation	+68°~+72°	70.3°
Melting Point	60~65°C	61-63°C
(HPLC)Assay	97-103.0%	98.71%
Free acid	0.5%max	0.35%
Conclusion	The above product conforms analysis standard

 

 

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Testosterone undecanoate description:

 

Its compound contains 40 mg of testosterone undecanoate based on oil and is sealed in capsules. Minus the ester weight, which is equivalent to about 25 mg of the testosterone dose per hat. This steroid is designed to be very different from most oral steroids. Oral administration of drugs usually flows through the liver into the bloodstream. When a steroid compound is administered in this manner without any form of structural protection .

 

 

This process leaves a very small steroid intact, essentially inactivating the drug. The addition of methyl (c-17AA) to the structure is a way to protect it from the process, but the results also apply pressure to the liver. In some cases, the stress can lead to actual damage to the liver tissue, so the designer of the steroid seeks another way to protect the testosterone molecule. With Andriol, which is produced by making a form of testosterone that will be absorbed through the lymphatic system. This is due to its high fat solubility caused by the ester and its suspension in the oil. It is believed that the absorption of the compound in this way is very advantageous because it allows the steroid to bypass the destructive first pass through the liver. This should allow the compound to enter the bloodstream completely without the need for harsh chemical changes. Once the ester breaks in the circulation, it produces the pharmacokinetics of free-acting oral testosterone. In the design, this steroid appears to be undecanoic, complete liver safe and oral active form of testosterone

 

 

Testosterone undecanoate Application:

 

Andriol or testosterone undecanoate is an ester of testosterone which is used for the treatment of male hypogonadism, and is currently under research for use as a male contraceptive, Andriol is sold and distributed under the brand names Andriol, understor, nebido, pantestone, restandol.

Testosterone undecanoate is a version of the anabolic steroid testosterone undecanoatedeveloped by the pharmaceutical company organon, testosterone is said to enter the body as a fat through the lymphatic system, experience from user indicates that in dose of less than 240mg per day, effects are negligible, except at every onset of use, while even in higher dose, effects are still minimal, Andriol is therefor thought that most of the steroid is somehow not making it into the blood stream.

 

 

Testosterone undecanoate dose:

 

The drug on paper seems to be a great oral testosterone product. Clean, safe and the world except for other oral testosterone derivatives such as mechild testosterone. But as we always hear in life, if it looks good, it is true that it might be. Andriol certainly has some problems. The first problem is bioavailability, although the apparent world in addition to trying to take direct testosterone orally, may not be significantly next to the c17alpha alkylated mouth. Athletes often find that at doses less than 240 mg / day (6 capsules), the effect is usually not seen at all. 240mg testosterone every day, the main male androgen, only weak effect. When the dose increases, it may be 8-10 capsules (320-400mg), the new muscle grows slightly to moderate, but did not report incredible huge gains. Logic leads people to believe that only one testosterone is flowing in a way. Testosterone is a powerful hormone, no matter what the ester or form of management. If it is active in the blood, the result must be pronounced. When a person injects an oil-based testosterone ester such as cyclopentanepropionate, the dose of 400 mg per week is sufficient to see the result. 400mg daily placebo should be packaged in an incredible quantity of quality. Where is all this? Personal absorption problems may play a role here. Obviously, there is little nothing to say, except that this medicine is unpredictable by its ability to be absorbed and utilized by the body. Although one day you may get a lot of absorption, maybe the next day you become very little The study with men was no better than women, again that the drug proved to be unpredictable to absorb and use blood levels ranging from 11.5 to 60.1 nmol / L with 80 mg twice daily.

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Testosterone Propionate	Nandrolone Decanoate	Melanotan-2
Testosterone Undecanoate	Nandrolone phenylpropionate	GHRP-2
Mesterone	Nandrolone undecylate	GHRP-6
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